our client is looking for an associate scientist in cambridge, ma. this is a long term position.
Job Description We are seeking motivated and creative individuals to join our Cell Line Development team through April 2013 and contribute to ongoing efforts to engineering superior host cell lines for the manufacturing of therapeutic proteins. The successful candidate will have mammalian cell culture/cell line development experience. Candidates with experience performing transfections, basic molecular ...
The laboratory technician prepares and weighs samples for testing and analysis. May setup and conduct tests, assays, and other protocols under the direction of a laboratory services manager, researcher, or scientist. Follow Standard Operating Procedures (SOPs) and Good Laboratory Practices (GLPs). Ensure all laboratory equipment and work areas are clean, sterile, and in proper working order. May be responsible for calibration of instruments and also involved in media prep.
The Structural Biophysics Group at the Novartis Institutes for BioMedical Research is looking for a talented and highly motivated scientist to assume a hands-on role in the use biophysical methods to characterize proteins, protein complexes and their interactions with small molecules. The candidate will actively participate in experimental design, performing experiments, and troubleshooting, as well as, performing data analysis and interpretation. The ideal candidate will be ...
seeking a technically skilled and highly motivated Assistant Laboratory Supervisor to provide technical support to staff performing moderate to high complexity testing of esoteric assays. As a member of our team you will be responsible for:
Cross-training laboratory staff on various testing platforms ensuring competency
Cross-validating assays on replicate instruments and/or methods
Coordinating the proficiency testing program for the clinical laboratory
Overseeing the validation and ...
Seeking expert knowledge of assay design and execution specifically for cell based assays, biochemical assays, and histological tests as well as a documented history of effective leadership in a drug discovery environment to lead a small scientific team focused on identifying and evaluating gene expressed proteins or peptides acting as renal biomarkers.
PhD relevant field and at least 4 years similar experience required.
Advance rapidly in this highly visible position. Top compensation package ...
Major developer of novel renal therapeutics seeks 3+ years experience and strong working knowledge of in vivo pharmacology techniques to:
*** Prepare test compounds
*** Handle and dose mice
*** Collect blood and tissue samples for PK and PD biomarker analysis
*** Establish PK-PD relationships from in vivo assays
*** Generate human dose predictions for clinical development
*** Assess the mechanism of action and therapeutic viability for novel renal therapies
PhD Life Sciences, ...
Seeking 3+ years experience developing topical dosage forms such as gels, creams, ointments, lotions, and novel delivery methods.
*** Conduct preformulation analysis physical and chemical characteristics of the drug and dispersed system including solubility, particle size distribution, surface area, polymorphism, surface tension, and rheology.
*** Analyze stability and release by visual evaluation, pH, chromatography, particle size analysis, and in vitro diffusion
*** Collaborate with ...
Seeking PhD and 2+ years experience in formulating transdermal drug delivery technologies and devices.
Must be familiar with:
*** Preformulation studies of the physical and chemical nature of transdermal drug products
*** Mix studies of complex pharmaceutical solutions, dispersions, and blends.
*** Equipment relating to mixing, coating, and packaging of transdermal products
*** Scale-up, tech transfer, and process optimization.
*** Preparing study protocols, SOPs, and reports
Seeking Ph.D. or M.D. and 10+ years in pre-clinical drug discovery and development for autoimmune, inflammation or respiratory therapeutic target entities including the development of in vivo, in vitro and ex vivo evaluation models.
*** Participate in selection of specific protein & antibody entities as novel targets or drug leads for therapeutic consideration and develop research strategy.
*** Supervise development of in vivo, in vitro and ex vivo evaluation models.
*** Oversee ...
Seeking a scientific leader to oversee the development of preclinical models of inflammatory diseases to support clinical development collaborations, based on the pathophysiology of disease and the mechanism of action of drugs.
*** Prepare, initiate, and manage all preclinical research studies
*** Establish collaborations with pharmaceutical and academic organizations
*** Manage a team of up to 10 Scientists
Candidate must have 10+ years similar experience and possess PhD in Biology, ...
Special Order Notes:
1.) Protein structural chemistry - characterization of protein variance
Biophysical type candidate
2.) Analytical methods
3.) Enzyme structure function / Biophysical methods
Forced degradation studies (how the molecules break apart)
Class of molecules in important and mechanisms of them.
Reverse Phase Chromotography
(No enzyme assay development)
Job Title: Postdoctoral Scientist
Apr 29 -
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